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In patients with focal segmental glomerulosclerosis (FSGS), in the absence of a deceased donor kidney transplantation program, is acceptable to transplant kidney from living donor, in spite of a known high recurrence of primiry disease?
Topics: disease recurrent
Answered by Diane Cibrik on May 02 2010 | Permalink
Although no randomized,prospective studies have been done to answer your question, a retrospective analysis using the USRDS and SRTR databases was performed to look at graft outcome in patients with FSGS that had a living donor kidney transplant (AJT 2003;3:64-67). In this analysis, patients with FSGS that received a zero mismatch living donor kidney transplant had similar death-censored graft survival as GN patients with a zero mismatch living donor kidney transplant (95% vs 93.3%). In addition, death-censored graft survival was superior for those FSGS patients that received a zero-mismatch living donor kidney transplant as compared to those FSGS patients that received a zero-mismatch deceased donor kidney transplant (95% vs 80.2%). Although this study does not address recurrence of FSGS directly, FSGS patients had similar graft outcomes as other patients with glomerulonephritis and should be offered living donor kidney transplant if available.
-Diane Cibrik
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